We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export.
- Authors
Sharon K. Kuss; Mata, Miguel A.; Liang Zhang; Fontoura, Beatriz M. A.
- Abstract
Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.
- Subjects
MESSENGER RNA; HOST plants; PLANT diseases; VIRAL disease prevention; VESICULAR stomatitis; GENETICS; PHYSIOLOGY
- Publication
Viruses (1999-4915), 2013, Vol 5, Issue 7, p1824
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v5071824