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- Title
Therapeutic Effect of a Polyherbal Formulation in Chronic Dysmenorrhea-Induced Mood Disorders.
- Authors
Ju Jin Tan; Choo Shiuan Por; Kow, Audrey Siew Foong; Rajagopal, Mogana; Ming Tatt Lee
- Abstract
Dysmenorrhea is often being neglected among women with the mindset that it is not life-threatening, treatment is sought only when present signs/symptoms. Previous studies have proven that women with dysmenorrhea are more susceptible to depression and anxiety as a result of menstrual pain. This research aims to study the potential therapeutic effect of MM-15 polyherbal formulation on chronic dysmenorrhea-associated mood disorders. Adult female ICR mice were employed in this study. Sixty non-pregnant mice were randomly grouped into six groups: estrogen + normal saline group; estrogen + oxytocin group; estrogen + oxytocin + purified water group; estrogen + oxytocin + MM-15 group (50mg/kg p.o.); estrogen + oxytocin + MM-15 group (100mg/kg p.o.); estrogen + oxytocin + MM-15 group (200mg/kg p.o.). Open field test (OFT), social interaction test (SIT) and tail suspension test (TST) were employed to measure the effect of MM-15 formulation on chronic dysmenorrhea-induced mood disorders. From the analyzed result, high dose of MM-15 formulation (200mg/kg, p.o.) increased the total distance travelled in OFT which indicated significantly reduction in anxiety-like response. In TST, the same dose of MM-15 formulation significantly showed potential antidepressant response by reducing immobility time. In SIT, all dose of MM-15 formulation does not improve social-withdrawal behavior in mice with chronic dysmenorrhea. Overall, MM-15 polyherbal formulation has a significant result in reducing chronic dysmenorrhea-induced mood disorders in mice, including depressive and anxiety-like behaviours.
- Subjects
AFFECTIVE disorders; TREATMENT effectiveness; LABORATORY mice; OXYTOCIN; ANXIETY; MENSTRUATION
- Publication
Current Trends in Biotechnology & Pharmacy, 2023, Vol 17, p25
- ISSN
0973-8916
- Publication type
Article