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Diagnostic value of skin RT-QuIC in Parkinson's disease: a two-laboratory study.
Published in:
NPJ Parkinson's Disease, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41531-021-00242-2
By:
- Kuzkina, Anastasia;
- Bargar, Connor;
- Schmitt, Daniela;
- Rößle, Jonas;
- Wang, Wen;
- Schubert, Anna-Lena;
- Tatsuoka, Curtis;
- Gunzler, Steven A.;
- Zou, Wen-Quan;
- Volkmann, Jens;
- Sommer, Claudia;
- Doppler, Kathrin;
- Chen, Shu G.
Publication type:
Article
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson's disease and dementia with Lewy bodies.
Published in:
Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01175-w
By:
- Bargar, Connor;
- Wang, Wen;
- Gunzler, Steven A.;
- LeFevre, Alexandra;
- Wang, Zerui;
- Lerner, Alan J.;
- Singh, Neena;
- Tatsuoka, Curtis;
- Appleby, Brian;
- Zhu, Xiongwei;
- Xu, Rong;
- Haroutunian, Vahram;
- Zou, Wen-Quan;
- Ma, Jiyan;
- Chen, Shu G.
Publication type:
Article
Cryptic Peptides of the Kringle Domains Preferentially Bind to Disease-Associated Prion Protein.
Published in:
Journal of Alzheimer's Disease, 2009, v. 16, n. 2, p. 421, doi. 10.3233/JAD-2009-0980
By:
- Hatcher, Kristen;
- Zheng, Jian;
- Chen, Shu G.
Publication type:
Article
Molecular profiling of paired helical filaments: Commentary on: Quantitative assessment of glycolipid and protein associated with paired helical filament preparations from Alzheimer's diseased brain by Warren J. Goux, Bingcam Liu, Abdurahman M. Shu...
Published in:
Journal of Alzheimer's Disease, 2001, v. 3, n. 5, p. 467, doi. 10.3233/JAD-2001-3505
By:
- Chen, Shu G.
Publication type:
Article
Assessing Prion Infectivity of Human Urine in Sporadic Creutzfeldt-Jakob Disease.
Published in:
Emerging Infectious Diseases, 2012, v. 18, n. 1, p. 21, doi. 10.3201/eid1801.110589
By:
- Notari, Silvio;
- Qing, Liuting;
- Pocchiari, Maurizio;
- Dagdanova, Ayuna;
- Hatcher, Kristin;
- Dogterom, Arend;
- Groisman, Jose F.;
- Lumholtz, Ib Bo;
- Puopolo, Maria;
- Lasmezas, Corinne;
- Chen, Shu G.;
- Kong, Qingzhong;
- Gambetti, Pierluigi
Publication type:
Article
Potential long‐term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1248, doi. 10.1002/alz.12465
By:
- Zheng, Chunlei;
- Fillmore, Nathanael R.;
- Ramos‐Cejudo, Jaime;
- Brophy, Mary;
- Osorio, Ricardo;
- Gurney, Mark E.;
- Qiu, Wei Qiao;
- Au, Rhoda;
- Perry, George;
- Dubreuil, Maureen;
- Chen, Shu G;
- Qi, Xin;
- Davis, Pamela B;
- Do, Nhan;
- Xu, Rong
Publication type:
Article
Overexpression of GRK2 in Alzheimer Disease and in a Chronic Hypoperfusion Rat Model is an Early Marker of Brain Mitochondrial Lesions.
Published in:
Neurotoxicity Research, 2006, v. 10, n. 1, p. 43, doi. 10.1007/BF03033333
By:
- Obrenovich, Mark E.;
- Smith, Mark A.;
- Siedlak, Sandra L.;
- Chen, Shu G.;
- De la Torre, Jack C.;
- Perry, George;
- Aliev, Gjumrakch
Publication type:
Article
Absence of protease-resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease.
Published in:
Journal of Pathology, 2001, v. 194, n. 1, p. 9, doi. 10.1002/path.872
By:
- Wong, Boon-Seng;
- Green, Alison J. E.;
- Li, Ruliang;
- Xie, Zhiliang;
- Pan, Tao;
- Liu, Tong;
- Chen, Shu G.;
- Gambetti, Pierluigi;
- Sy, Man-Sun
Publication type:
Article
P4-162: LRRK2 in Lewy bodies of Parkinson’s disease and dementia with Lewy bodies
Published in:
2006
By:
- Smith, Mark A.;
- Zhu, Xiongwei;
- Babar, Asim;
- Siedlak, Sandra L.;
- Yang, Qiwei;
- Ito, Genta;
- Iwatsubo, Takeshi;
- Perry, George;
- Chen, Shu G.
Publication type:
Abstract
P1-423: Functional studies of a novel protein kinase LRRK2 provide insights into pathogenesis of Parkinson’s disease
Published in:
2006
By:
- Guo, Luxuan;
- Wang, Wen;
- Gandhi, Payal N.;
- Wilson-Delfosse, Amy L.;
- Chen, Shu G.
Publication type:
Abstract
P4-162: LRRK2 in Lewy bodies of Parkinson’s disease and dementia with Lewy bodies
Published in:
2006
By:
- Smith, Mark A.;
- Zhu, Xiongwei;
- Babar, Asim;
- Siedlak, Sandra L.;
- Yang, Qiwei;
- Ito, Genta;
- Iwatsubo, Takeshi;
- Perry, George;
- Chen, Shu G.
Publication type:
Abstract
P1-423: Functional studies of a novel protein kinase LRRK2 provide insights into pathogenesis of Parkinson’s disease
Published in:
2006
By:
- Guo, Luxuan;
- Wang, Wen;
- Gandhi, Payal N.;
- Wilson-Delfosse, Amy L.;
- Chen, Shu G.
Publication type:
Abstract
The primary pathogenetic role of vascular contains vasoactive substances, hypoperfusion, mitochondria failure and oxidative stress in aging and Alzheimer disease
Published in:
2005
By:
- Aliev, Gjumrakch;
- Perry, George;
- Liu, Jiankang;
- Smith, Mark A.;
- Chen, Shu G.;
- Ames, Bruce N.;
- de la Torre, Jack C.
Publication type:
Abstract
Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type.
Published in:
Scientific Reports, 2017, p. 38280, doi. 10.1038/srep38280
By:
- Cracco, Laura;
- Notari, Silvio;
- Cali, Ignazio;
- Sy, Man-Sun;
- Chen, Shu G.;
- Cohen, Mark L.;
- Ghetti, Bernardino;
- Appleby, Brian S.;
- Zou, Wen-Quan;
- Caughey, Byron;
- Safar, Jiri G.;
- Gambetti, Pierluigi
Publication type:
Article
Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.
Published in:
Scientific Reports, 2016, p. 34477, doi. 10.1038/srep34477
By:
- Chen, Shu G.;
- Stribinskis, Vilius;
- Rane, Madhavi J.;
- Demuth, Donald R.;
- Gozal, Evelyne;
- Roberts, Andrew M.;
- Jagadapillai, Rekha;
- Liu, Ruolan;
- Choe, Kyonghwan;
- Shivakumar, Bhooma;
- Son, Francheska;
- Jin, Shunying;
- Kerber, Richard;
- Adame, Anthony;
- Masliah, Eliezer;
- Friedland, Robert P.
Publication type:
Article
Paradoxical Role of Prion Protein Aggregates in Redox-Iron Induced Toxicity.
Published in:
PLoS ONE, 2010, v. 5, n. 7, p. 1, doi. 10.1371/journal.pone.0011420
By:
- Das, Dola;
- Xiu Luo;
- Singh, Ajay;
- Gu, Yaping;
- Ghosh, Soumya;
- Mukhopadhyay, Chinmay K.;
- Chen, Shu G.;
- Sy, Man-Sun;
- Kong, Qingzhong;
- Singh, Neena
Publication type:
Article
Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies.
Published in:
Neurodegenerative Diseases, 2008, v. 5, n. 3/4, p. 222, doi. 10.1159/000113708
By:
- Perry, George;
- Xiongwei Zhu;
- Babar, Asim K.;
- Siedlak, Sandra L.;
- Qiwei Yang;
- Ito, Genta;
- Iwatsubo, Takeshi;
- Smith, Mark A.;
- Chen, Shu G.
Publication type:
Article
DNA Aptamers That Bind to PrP C and Not Prp Sc Show Sequence and Structure Specificity.
Published in:
Experimental Biology & Medicine, 2006, v. 231, n. 2, p. 204, doi. 10.1177/153537020623100211
By:
- Takemura, Kaori;
- Wang, Ping;
- Vorberg, Ina;
- Surewicz, Witold;
- Priola, Suzette A.;
- Kanthasamy, Anumantha;
- Pottathil, Ravi;
- Chen, Shu G.;
- Sreevatsan, Srinand
Publication type:
Article
Sensitive Detection of Prion Protein in Human Urine.
Published in:
Experimental Biology & Medicine, 2005, v. 230, n. 5, p. 343, doi. 10.1177/153537020523000508
By:
- Narang, Harash K.;
- Dagdanova, Ayuna;
- Xie, Zhiliang;
- Yang, Qiwei;
- Chen, Shu G.
Publication type:
Article
Chronic Wasting Disease of Elk: Transmissibility to Humans Examined by Transgenic Mouse Models.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 35, p. 7944, doi. 10.1523/JNEUROSCI.2467-05.2005
By:
- Qingzhong Kong;
- Shenghai Huang;
- Wenquan Zou;
- Vanegas, Difernando;
- Meiling Wang;
- Di Wu;
- Jue Yuan;
- Mengjie Zheng;
- Hua Bai;
- Huayun Deng;
- Chen, Ken;
- Jenny, Allen L.;
- O'Rourke, Katherine;
- Belay, Ermias D.;
- Schonberger, Lawrence B.;
- Petersen, Robert B.;
- Man-Sun Sy;
- Chen, Shu G.;
- Gambetti, Pierluigi
Publication type:
Article
Protease-Resistant Human Prion Protein and Ferritin Are Cotransported across Caco-2 Epithelial Cells: Implications for Species Barrier in Prion Uptake from the Intestine.
Published in:
Journal of Neuroscience, 2004, v. 24, n. 50, p. 11280, doi. 10.1523/JNEUROSCI.2864-04.2004
By:
- Mishra, Ravi Shankar;
- Basu, Subhabrata;
- Yaping Gu;
- Xiu Luo;
- Wen-Quan Zou;
- Mishra, Richa;
- Ruliang Li;
- Chen, Shu G.;
- Gambetti, Pierluigi;
- Fujioka, Hisashi;
- Singh, Neena
Publication type:
Article
Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease.
Published in:
JAMA Neurology, 2021, v. 78, n. 1, p. 30, doi. 10.1001/jamaneurol.2020.3311
By:
- Wang, Zerui;
- Becker, Katelyn;
- Donadio, Vincenzo;
- Siedlak, Sandra;
- Yuan, Jue;
- Rezaee, Masih;
- Incensi, Alex;
- Kuzkina, Anastasia;
- Orrú, Christina D.;
- Tatsuoka, Curtis;
- Liguori, Rocco;
- Gunzler, Steven A.;
- Caughey, Byron;
- Jimenez-Capdeville, Maria E.;
- Zhu, Xiongwei;
- Doppler, Kathrin;
- Cui, Li;
- Chen, Shu G.;
- Ma, Jiyan;
- Zou, Wen-Quan
Publication type:
Article
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.
Published in:
Journal of Cellular & Molecular Medicine, 2009, v. 13, n. 2, p. 320, doi. 10.1111/j.1582-4934.2008.00324.x
By:
- Aliev, Gjumrakch;
- Jiankang Liu;
- Justin C. Shenk;
- Fischbach, Kathryn;
- Pacheco, Gerardo J.;
- Chen, Shu G.;
- Obrenovich, Mark E.;
- Ward, Walter F.;
- Richardson, Arlan G.;
- Smith, Mark A.;
- Gasimov, Eldar;
- George Perry;
- Ames, Bruce N.
Publication type:
Article
Divalent metal transporter, iron, and Parkinson's disease: A pathological relationship.
Published in:
Cell Research, 2010, v. 20, n. 4, p. 397, doi. 10.1038/cr.2010.39
By:
- Hyun-pil Lee;
- Xiongwei Zhu;
- Gang Liu;
- Chen, Shu G.;
- Perry, George;
- Smith, Mark A.;
- Hyoung-gon Lee
Publication type:
Article
Molecular Pathology of Fatal Familial Insomnia.
Published in:
Brain Pathology, 1998, v. 8, n. 3, p. 539, doi. 10.1111/j.1750-3639.1998.tb00176.x
By:
- Parchi, Piero;
- Petersen, Robert B.;
- Chen, Shu G.;
- Autilio-Gambetti, L.;
- Capellari, Sabina;
- Monari, Lucia;
- Cortelli, Pietro;
- Montagna, Pasquale;
- Lugaresi, Elio;
- Gambetti, Pierluigi
Publication type:
Article
Fatal Familial Insomnia and Familial Creutzfeldt-Jakob Disease: Clinical, Pathological and Molecular Features.
Published in:
Brain Pathology, 1995, v. 5, n. 1, p. 43, doi. 10.1111/j.1750-3639.1995.tb00576.x
By:
- Gambetti, Pierluigi;
- Parchi, Piero;
- Petersen, Robert B.;
- Chen, Shu G.;
- Lugaresi, Elio
Publication type:
Article
LRRK2 protein is a component of Lewy bodies.
Published in:
2006
By:
- Zhu X;
- Siedlak SL;
- Smith MA;
- Perry G;
- Chen SG;
- Zhu, Xiongwei;
- Siedlak, Sandra L;
- Smith, Mark A;
- Perry, George;
- Chen, Shu G
Publication type:
Letter
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.
Published in:
Human Molecular Genetics, 2015, v. 24, n. 5, p. 1322, doi. 10.1093/hmg/ddu542
By:
- Johnson, William M.;
- Yao, Chen;
- Siedlak, Sandra L.;
- Wang, Wenzhang;
- Zhu, Xiongwei;
- Caldwell, Guy A.;
- Wilson-Delfosse, Amy L.;
- Mieyal, John J.;
- Chen, Shu G.
Publication type:
Article
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.
Published in:
Human Molecular Genetics, 2013, v. 22, n. 2, p. 328, doi. 10.1093/hmg/dds431
By:
- Yao, Chen;
- Johnson, William M.;
- Gao, Yue;
- Wang, Wen;
- Zhang, Jinwei;
- Deak, Maria;
- Alessi, Dario R.;
- Zhu, Xiongwei;
- Mieyal, John J.;
- Roder, Hanno;
- Wilson-Delfosse, Amy L.;
- Chen, Shu G.
Publication type:
Article
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Published in:
Human Molecular Genetics, 2012, v. 21, n. 9, p. 1931, doi. 10.1093/hmg/dds003
By:
- Wang, Xinglong;
- Yan, Michael H.;
- Fujioka, Hisashi;
- Liu, Jun;
- Wilson-Delfosse, Amy;
- Chen, Shu G.;
- Perry, George;
- Casadesus, Gemma;
- Zhu, Xiongwei
Publication type:
Article
Sporadic and familial CJD: classification and characterisation.
Published in:
British Medical Bulletin, 2003, v. 66, n. 1, p. 213, doi. 10.1093/bmb/66.1.213
By:
- Pierluigi Gambetti;
- Qingzhong Kong;
- Wenquan Zou;
- Piero Parchi;
- Shu G Chen
Publication type:
Article
LRRK2 in Parkinson's disease and dementia with Lewy bodies.
Published in:
Molecular Neurodegeneration, 2006, v. 1, p. 17, doi. 10.1186/1750-1326-1-17
By:
- Xiongwei Zhu;
- Babar, Asim;
- Siedlak, Sandra L.;
- Qiwei Yang;
- Ito, Genta;
- Iwatsubo, Takeshi;
- Smith, Mark A.;
- Perry, George;
- Chen, Shu G.
Publication type:
Article
Gut–microbiota–microglia–brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization.
Published in:
Alzheimer's Research & Therapy, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13195-021-00917-1
By:
- Wang, QuanQiu;
- Davis, Pamela B.;
- Qi, Xin;
- Chen, Shu G.;
- Gurney, Mark E.;
- Perry, George;
- Doraiswamy, P. Murali;
- Xu, Rong
Publication type:
Article
Molecular basis of phenotypic variability in sporadc creudeldt-jakob disease.
Published in:
Annals of Neurology, 1996, v. 39, n. 6, p. 767, doi. 10.1002/ana.410390613
By:
- Parchi, Piero;
- Castellani, Rudolph;
- Capellari, Sabina;
- Ghetti, Bernardino;
- Young, Katherine;
- Chen, Shu G.;
- Farlow, Martin;
- Dickson, Dennis W.;
- Sima, Anders A. F.;
- Trojanowski, John Q.;
- Petersen, Robert B.;
- Gambetti, Pierluigi
Publication type:
Article
Regional distribution of protease-resistant prion protein in fatal familial insomnia.
Published in:
Annals of Neurology, 1995, v. 38, n. 1, p. 21, doi. 10.1002/ana.410380107
By:
- Parchi, Piero;
- Castellani, Rudy;
- Cortelli, Pietro;
- Montagna, Pasquale;
- Chen, Shu G.;
- Petersen, Robert B.;
- Manetto, Valeria;
- Vnencak-Jones, Cindy L.;
- McLean, Michael J.;
- Sheller, James R.;
- Lugaresi, Elio;
- Autilio-Gambetti, Lucila;
- Gambetti, Pierluigi
Publication type:
Article
A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson's disease.
Published in:
Acta Neuropathologica Communications, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40478-024-01873-1
By:
- Wang, Zerui;
- Gilliland, Tricia;
- Kim, Hyun Jo;
- Gerasimenko, Maria;
- Sajewski, Kailey;
- Camacho, Manuel V.;
- Bebek, Gurkan;
- Chen, Shu G.;
- Gunzler, Steven A.;
- Kong, Qingzhong
Publication type:
Article

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