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- Title
Methyl-β-D-glucopyranoside From Scabiosa comosa as a Quorum-Sensing Inhibitor.
- Authors
Davaapurev, Bekh-Ochir; Fukumoto, Atsushi; Bolortuya, Byambajav; Boldbaatar, Delgerbat; Maehata, Yoshino; Iizaka, Yohei; Kato, Fumio; Batkhuu, Javzan; Anzai, Yojiro
- Abstract
Quorum sensing (QS) is an important microbial signaling system that controls the expression of many virulence genes. Combination treatment with QS inhibitors and antibiotics may be the new treatment option for infectious diseases in the future. Therefore, there is an increasing need to discover anti-QS compounds to prevent antimicrobial resistance. We isolated methyl-β-D-glucopyranoside from Scabiosa comosa and found that it exerts an anti-QS activity against Chromobacterium violaceum CV026 without exhibiting any antimicrobial activity.
- Subjects
CHROMOBACTERIUM violaceum; QUORUM sensing; DRUG resistance in microorganisms; ANTI-infective agents; COMMUNICABLE diseases
- Publication
Natural Product Communications, 2022, Vol 17, Issue 11, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X221139972