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- Title
Triterpene Tetraglycosides From Stichopus Herrmanni Semper, 1868.
- Authors
Vien, Le Thi; Hanh, Tran Thi Hong; Quang, Tran Hong; Thanh, Nguyen Van; Thao, Do Thi; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Thung, Do Cong; Van Kiem, Phan
- Abstract
Using various column chromatographic methods, 5 triterpene tetraglycosides (1 − 5), including one new compound, namely holothurin A6 (1), were obtained from the water soluble part of the methanol extract of the sea cucumber Stichopus herrmanni. Their structures were confirmed by careful analysis of the 1D and 2D NMR, and HR ESI QTOF mass spectra. Noteworthily, 24-dehydroechinoside A (3) showed potent cytotoxicity to 5 human cancer cell lines {HepG2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma)} with IC50 values ranging from 0.19 ± 0.03 to 1.17 ± 0.18 µM.
- Subjects
SQUAMOUS cell carcinoma; PROSTATE cancer; MASS spectrometry; SEA cucumbers; CELL lines; TRITERPENES
- Publication
Natural Product Communications, 2022, Vol 17, Issue 5, p1
- ISSN
1934-578X
- Publication type
Article
- DOI
10.1177/1934578X221105369