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- Title
Low intake of digestible carbohydrates ameliorates duodenal absorption of carbohydrates in mice with glucose metabolism disorders induced by artificial sweeteners.
- Authors
Shi, Qing; Cai, Lei; Jia, Hongzhe; Zhu, Xuemei; Chen, Lei; Deng, Shaoping
- Abstract
Background: Long‐term artificial sweetener consumption has been reported to induce glucose intolerance, and the intestinal microbiota seems as an important target. While the impacts of artificial sweeteners on energy balance remain controversial, this work aimed to evaluate the protective effects in mice of a low digestible carbohydrate (LDC) diet on plasma glucose, plasma fasting insulin, sweet taste receptors, glucose transporters, and absorption of carbohydrates, together with consumption of acesulfame potassium (AK) or saccharin (SAC). Results: Artificial sweetener was administered to mice for 12 weeks to induce glucose metabolism disorders; mice were treated with an LDC diet for the final 6 weeks. The experimental groups were treated with an LDC diet that had the same energy as the normal‐diet group. Prolonged administration of artificial sweeteners led to metabolic dysfunction, characterized by significantly increased plasma glucose, insulin resistance, sweet taste receptors, glucose transporters, and absorption of carbohydrates. Treatment with an LDC diet positively modulated these altered parameters, suggesting overall beneficial effects of an LDC diet on detrimental changes associated with artificial sweeteners. Conclusions: Reducing digestible carbohydrates in the diet can significantly reduce the absorption of carbohydrates and improve glucose metabolism disorders caused by dietary factors. These effects may be due to the fact that reducing the amount of digestible carbohydrates in the feed can reduce the number of intestinal sweet receptors induced by exposure to artificial sweeteners. © 2019 Society of Chemical Industry
- Subjects
SOCIETY of Chemical Industry (Great Britain); GLUCOSE metabolism disorders; NONNUTRITIVE sweeteners; CARBOHYDRATE content of food; CARBOHYDRATES; ACESULFAME-K; TASTE receptors
- Publication
Journal of the Science of Food & Agriculture, 2019, Vol 99, Issue 11, p4952
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.9727