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- Title
Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome.
- Authors
Kyong-Su Park; Kyoung-Ho Choi; You-Sun Kim; Bok Sil Hong; Oh Youn Kim; Ji Hyun Kim; Chang Min Yoon; Gou-Young Koh; Yoon-Keun Kim; Yong Song Gho
- Abstract
Sepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical bilayered proteolipids. Using a mouse model, we showed that intraperitoneal injection of OMVs derived from intestinal Escherichia coli induced lethality. Furthermore, OMVs induced host responses which resemble a clinically relevant condition like sepsis that was characterized by piloerection, eye exudates, hypothermia, tachypnea, leukopenia, disseminated intravascular coagulation, dysfunction of the lungs, hypotension, and systemic induction of tumor necrosis factor-α and interleukin-6. Our study revealed a previously unidentified causative microbial signal in the pathogenesis of sepsis, suggesting OMVs as a new therapeutic target to prevent and/or treat severe sepsis caused by Gramnegative bacterial infection.
- Subjects
ESCHERICHIA coli; SEPSIS; GRAM-negative bacterial diseases; GRAM-negative bacteria; HYPOTHERMIA; BLOOD coagulation disorders; LUNG diseases; HYPOTENSION; TUMOR necrosis factors
- Publication
PLoS ONE, 2010, Vol 5, Issue 6, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0011334