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- Title
Célzott terápiák a reumatológiai gyakorlatban: előnyök és hátrányok.
- Authors
EDIT, VERECKEI
- Abstract
The clinical picture of inflammatory and autoimmune diseases is shaped by the network of proinflammatory cytokines and their receptors, and by the specificity of associated intracellular signal transduction proteins. Pathomechanisms and tissue responses of autoimmune, immune-mediated inflammatory and autoinflammatory pathologies and syndromes generate complex and multifaceted symptom complexes. Cytokine signalling is structured hierarchically, with well identifiable nodes and bran ches. Elements of the system are in dialogue and in homeostatic self-regulatory interrelations. The cytokine network and clinical pictures may be represented as a matrix. Autoaggressive dysregulation re sults in pathologic conditions. The innovative, targeted therapy means pharmacological inhibition of central players in pathogenesis. Its tools are engineered complementary protein macromolecules (genetically engineered monoclonal antibodies and receptor analogues or fusion proteins), further small molecule enzyme inhibitors engineered also for targeting. By unprecedented efficacy and manageable toxicity, they change profoundly the nature of target diseases and result in near-remission or similar conditions. This study presents the targeted mechanisms and diseases, further the inhibitory pharmaceutical products.
- Subjects
INFLAMMATION treatment; AUTOIMMUNE disease treatment; HEMOSTATICS; ENZYME inhibitors; MONOCLONAL antibodies; SMALL molecules; AUTOIMMUNE diseases; INFLAMMATION; CYTOKINES; CELL receptors; SIGNAL peptides
- Publication
Lege Artis Medicine (LAM), 2024, Vol 34, Issue 5/6, p285
- ISSN
0866-4811
- Publication type
Article
- DOI
10.33616/lam.34.0285