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- Title
Fat, Cartilage, and Bone Metaplasia in Lungs of Cattle With Caudal Pleural Lesions and Subjacent Interstitial Fibrosis.
- Authors
Ramírez-Hernández, Cecilia; García-Márquez, Luis Jorge; Decanini-Arcaute, Horacio; Martínez-Burnes, Julio; Ramírez-Romero, Rafael
- Abstract
The changes associated with condemned lungs in cattle with chronic pleural lesions of the caudal lobes were characterized by histology and immunohistochemistry (IHC). Fibroproliferative pleural lesions were microscopically confirmed. Occasionally, the pleural lesions also included adipose, chondroid, and osseous metaplasia that were covered by mesothelial cells, mostly in the absence of inflammation. Other lungs also showed fibrosis in the subpleural interstitium and interlobular septa. In both condemned and noncondemned lungs, immunoreactivity to Wilms tumor 1 (WT1) was normally observed on surface mesothelial cells but not on the submesothelial fibroblasts and myofibroblasts. Conversely, the myofibroblasts beneath the pleura, but not the mesothelial cells, showed immunoreactivity to alpha smooth muscle actin and calponin. However, in the lungs with myofibroblastic foci in the pleura, the proliferated cells maintained WT1 immunoreactivity similar to those of some metaplastic cells. These findings may reflect the plasticity of mesothelial cells in vivo.
- Subjects
PLEURA; METAPLASIA; LUNGS; CARTILAGE; NEPHROBLASTOMA; CATTLE
- Publication
Veterinary Pathology, 2019, Vol 56, Issue 4, p599
- ISSN
0300-9858
- Publication type
Article
- DOI
10.1177/0300985819837719