We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Investigating the Bismuth Complexes with Benzoazacrown Tri‐ and Tetra‐Acetates.
- Authors
Egorova, Bayirta V.; Matazova, Ekaterina V.; Aleshin, Gleb Yu.; Zubenko, Anastasia D.; Pashanova, Anna V.; Konopkina, Ekaterina A.; Mitrofanov, Artem A.; Smirnova, Anastasia A.; Trigub, Alexander L.; Karnoukhova, Valentina A.; Fedorova, Olga A.; Kalmykov, Stepan N.
- Abstract
The complexation properties towards Bi3+ of benzoazacrown ligands with five (H3BA3A) and six (H4BATA) heteroatoms and corresponding number of acetic arms have been investigated. Complexation constants were determined via potentiometric titration for BA3ABi complex (logβ=26.2) and refined for BATABi complex (logβ=31.7). According to NMR, X‐ray and EXAFS results, chelation of cation by H3BA3A appears to be outside the macrocyclic cavity both in the solid state and in the aqueous solution. This out‐cage location despite the high stability constant causes serum and in vivo instability of complex of smaller azacrown H3BA3A in contrast to H4BATA. Whereas the larger macrocycle and four pendant arms of H4BATA provide long‐range coordination effectively shielding the cation thereby ensuring high inertness in vitro, low accumulation of the radionuclide in the organs, and fast clearance.
- Subjects
STABILITY constants; BISMUTH; POTENTIOMETRY; AQUEOUS solutions; CHELATION; RADIOISOTOPES
- Publication
European Journal of Inorganic Chemistry, 2021, Vol 2021, Issue 33, p3344
- ISSN
1434-1948
- Publication type
Article
- DOI
10.1002/ejic.202100256