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- Title
Toward an Asymmetric Synthesis of Bistramide K.
- Authors
Bauder, Claude
- Abstract
The bistramides family has shown antitumoral activity. More specifically bistramide K exhibits lower toxicity than its congeners. In this work, we describe a highly stereoselective and convergent synthesis of two building blocks of the marine metabolite bistramide K. Thus, we report the synthesis of fragments C1–C18 (89) and C19–C40 (81) of bistramide K. As a challenge, we have used nonracemic methyl p‐tolyl sulfoxide as unique source of chirality for the elaboration of all stereogenic centers of the natural compound.
- Subjects
ASYMMETRIC synthesis; AMIDES; ANTINEOPLASTIC agents; SULFOXIDES; CHIRALITY; MARINE metabolites
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 35, p4874
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201800875