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- Title
Practical guidance for clinical laboratories for SARS-CoV-2 serology testing.
- Authors
Charlton, Carmen; Kanji, Jamil; Tran, Vanessa; Kus, Julianne; Gubbay, Jonathan; Osiowy, Carla; Robinson, Jason; Sekirov, Inna; Drebot, Michael; Hatchette, Todd; Stein, Derek; El-Gabalawy, Nadia; Lang, Amanda; Lei Jiao; Levett, Paul; Wood, Heidi; Therrien, Christian; Lindsay, L. Robbin; Morshed, Muhammad; Forbes, Jessica
- Abstract
The landscape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing is rapidly evolving. While serology testing has limited diagnostic capacity for acute infection, its role in providing population-based information on positivity rates and informing evidence-based decision making for public health recommendations is increasing. With the global availability of vaccines, there is increasing pressure on clinical laboratories to provide antibody screening and result interpretation for vaccinated and non-vaccinated individuals. Here we present the most up-to-date data on SARS-CoV-2 antibody timelines, including the longevity of antibodies, and the production and detection of neutralizing antibodies. Additionally, we provide practical guidance for clinical microbiology laboratories to both verify commercial serology assays and choose appropriate testing algorithms for their local populations.
- Subjects
SARS-CoV-2; PATHOLOGICAL laboratories; SEROLOGY; MEDICAL microbiology; COVID-19
- Publication
Canada Communicable Disease Report, 2021, Vol 47, Issue 4, p171
- ISSN
1188-4169
- Publication type
journal article
- DOI
10.14745/ccdr.v47i04a01