We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hyperphosphatemia of chronic kidney disease.
- Authors
Hruska, Keith A.; Mathew, Suresh; Lund, Richard; Ping Qiu; Pratt, Raymond
- Abstract
Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. This review describes the pathobiology of hyperphosphatemia that develops as a consequence of positive phosphate balance in chronic kidney disease and the mechanisms by which hyperphosphatemia acts on neointimal vascular cells that are stimulated to mineralize in chronic kidney disease. The characterization of hyperphosphatemia of chronic kidney disease as a distinct syndrome in clinical medicine with unique disordered skeletal remodeling, heterotopic mineralization and cardiovascular morbidity is presented.Kidney International (2008) 74, 148–157; doi:10.1038/ki.2008.130; published online 30 April 2008
- Subjects
KIDNEY diseases; CHRONIC kidney failure; CALCIFICATION; PHOSPHATES; CLINICAL medicine research; CARDIOVASCULAR diseases; STIMULUS synthesis
- Publication
Kidney International, 2008, Vol 74, Issue 2, p148
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2008.130