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- Title
A multi-step approach to overcome challenges in the management of head and neck lymphatic malformations, and response to treatment.
- Authors
Trevisan, Valentina; De Corso, Eugenio; Viscogliosi, Germana; Onesimo, Roberta; Cina, Alessandro; Panfili, Marco; Perri, Lucrezia; Agazzi, Cristiana; Giorgio, Valentina; Rigante, Donato; Vento, Giovanni; Papacci, Patrizia; Paradiso, Filomena Valentina; Silvaroli, Sara; Nanni, Lorenzo; Resta, Nicoletta; Castori, Marco; Galli, Jacopo; Paludetti, Gaetano; Zampino, Giuseppe
- Abstract
Background: Lymphatic malformations are vascular developmental anomalies varying from local superficial masses to diffuse infiltrating lesions, resulting in disfigurement. Patients' outcomes range from spontaneous regression to severe sequelae notwithstanding appropriate treatment. The current classification guides, in part, clinicians through the decision-making process, prognosis prediction and choice of therapeutic strategies. Even though the understanding of molecular basis of the disease has been recently improved, a standardized management algorithm has not been reached yet. Results: Here, we report our experience on five children with different lymphatic anomalies of the head and neck region treated by applying a multidisciplinary approach reaching a consensus among specialists on problem-solving and setting priorities. Conclusions: Although restitutio ad integrum was rarely achieved and the burden of care is challenging for patients, caregivers and healthcare providers, this study demonstrates how the referral to expert centres can significantly improve outcomes by alleviating parental stress and ameliorating patients' quality of life. A flow-chart is proposed to guide the multidisciplinary care of children with LMs and to encourage multidisciplinary collaborative initiatives to implement dedicated patients' pathways.
- Subjects
LYMPHATIC abnormalities; MEDICAL personnel; BURDEN of care; PSYCHOLOGICAL stress; NECK; QUALITY of life
- Publication
Orphanet Journal of Rare Diseases, 2024, Vol 19, Issue 1, p1
- ISSN
1750-1172
- Publication type
Article
- DOI
10.1186/s13023-024-03200-2