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- Title
Pro-inflammatory mediators increase levels of the noncoding RNA GAS5 in airway smooth muscle and epithelial cells<sup>1</sup>.
- Authors
Keenan, Christine R.; Schuliga, Michael J.; Stewart, Alastair G.
- Abstract
The long noncoding RNA (lncRNA) GAS5 has been found to act as a decoy for the glucocorticoid receptor (GR), thus implicating GAS5 as a potential regulator of glucocorticoid sensitivity and resistance. Airway smooth muscle (ASM) cells and airway epithelial cells (AEC) play an important role in the pathogenesis and persistence of asthma and other chronic airways diseases. These airway structural cell types are also important cellular targets of the anti-inflammatory actions of glucocorticoids. In this study, we sought to examine the relevance of GAS5 to glucocorticoid sensitivity and resistance in ASM and AEC. We provide the first evidence that pro-inflammatory mediators up-regulate GAS5 levels in both airway epithelial and smooth muscle cells, and that decreasing GAS5 levels can enhance glucocorticoid action in AEC.
- Subjects
NON-coding RNA; MUSCLE cells; INFLAMMATORY mediators; EPITHELIAL cells; SMOOTH muscle
- Publication
Canadian Journal of Physiology & Pharmacology, 2015, Vol 93, Issue 3, p203
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2014-0391