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- Title
D-Penicillamine in Vivo Enhances Lymphocyte DNA Synthesis: Role of Macrophages.
- Authors
Binderup, L.; Bramm, E.; Arrigoni-Martelli, E.
- Abstract
administration of D-penicillamine (50 mg/kg/day orally) for 4 days increased the uptnke- of ³H-lhymidine (³H-TdR) in unstimulated and concanaviilin-A-stimulated unseparated lymph node and spleen cells from Lewis rats. Increased ³H-TdR incorporation was also found in cultures depleted of adherent cells. D-Penicilamine treatment did not increase the incorporation of ³H-TdR in lymph node and spleen cells from rats concomitantly treated with the selective macrophage toxin silica. In contrast, treatment with D-penicillamine during the last 4 days of silica treatment sometimes resulted in a marked decrease in ³H-TdR incorporation. It is suggested that D-penicillamine treatment in vivo is able lo enhance the responsiveness of the lymphocytes, dependent on [tie presence of functionally infact macropliages. The increased response vanished after 2-3 weeks, even with continuous administration of D-pen cilltimine.
- Subjects
PENICILLAMINE; LYMPHOCYTES; KILLER cells; MURIDAE; SILICON compounds; LEUCOCYTES
- Publication
Scandinavian Journal of Immunology, 1980, Vol 11, Issue 1, p23
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1980.tb00204.x