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- Title
The Use of Bacteria for the Functional Characterization of Human Lymphocyte Subpopulations in Various Lymphoid Organs.
- Authors
Rynnel-Dagöö, B.; Ringdén, O.; Alfredsson, H.; Möller, E.
- Abstract
In a haemolytic plaque assay staphylococcal strain Cowan 1 was shown to induce polyclonal antibody secretion In human blood lymphocytes, whereas Haemophilus influenzac and Escherichia coli gave low responses. Diplococcus pneumoniae and haemoiytic streptococci generally did not activate blood cells. All five bacteria could activate spleen, tonsil and adenoid cells both to polyclonal Ig secretion and increased DNA synthesis. Thus blood cell reactivity does not necessarily reflect the response pattern in other lymphatic organs. The adenoid was shown to contain lymphocytes more responsive to bacteria normally residing in nasopharynx than cells residing in other lymphatic organs. On the other hand, spleen and mesenteric lymph node contain a subpopulation of cells highly responsive to bacteria such as Escherichia coli normally residing in the bowel. Therefore, we conclude that there exists a functional compartmentalization of lymphocytes in distinct secondary lymphoid organs.
- Subjects
HEMOLYTIC plaque technique; ESCHERICHIA coli; STREPTOCOCCUS; IMMUNOGLOBULINS; DNA synthesis; BACTERIA
- Publication
Scandinavian Journal of Immunology, 1978, Vol 8, Issue 5, p369
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1978.tb00531.x