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- Title
N-Terminal Amino Acid Sequence of Amyloid Fibril Protein AR, Prototype of a New λ-Variable Subgroup, VλV.
- Authors
Sletten, K.; Husby, G.; Natvig, J. B.
- Abstract
An amyloid fibril protein AR has been further characterized as to amino acid sequence of the first 45 N-terminal residues. There are clear homologies with light chain-variable regions, particularly with λ light chains and mostly with the VλII subgroup. However, there is as much as a 55% difference from the VλII subgroup and even greater differences from other subgroups. This is much more than the variation known to occur within a given light chain-variable subgroup and also a greater difference than those known to occur between the existing subgroups. For this reason protein AR appears to be the prototype for a new variable subgroup of λ chains. In agreement with the National Biomedical Research Foundation, this new subgroup is termed VλV.
- Subjects
AMINO acid sequence; AMINO acids; AMYLOID beta-protein; HOMOLOGY (Biology); MEDICAL research; ORGANIC acids
- Publication
Scandinavian Journal of Immunology, 1974, Vol 3, Issue 6, p833
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1974.tb01319.x