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- Title
Response of Specific Skin Hypersensitivity and Haemagglutination Inhibiting Antibody after Smallpox Vaccination in Human Newborns and Adults.
- Authors
Saha, K.; Chawla, S. L.; Saini, L.; Gupta, S.
- Abstract
We tried to assess the response of the specific cell-mediated and humoral immunity after primary smallpox vaccination in normal full term newborns and compared these results with those found in revaccinated adults. Revaccination and intradermal inoculation of heat-inactivated vaccinia virus were the two methods employed to study the specific delayed hypersensitivity against this virus. We found that, although these newborn babies were able to produce haemagglutination inhibiting (HI) antibody even more efficiently than the adults, the skin hypersensitivity developed in them after primary vaccination was of much lower extent than in the revaccinated adults. The HI antibody response in the vaccinated newborns was initially 2-ME sensitive (100%), while in the revaccinated adults the early HI antibodies were mixed varieties, i.e. both 2-ME sensitive (38.6%) and 2-ME resistant (61.4%); then there was a gradual shift towards 2-ME resistant HI antibody in the newborns. In adults the humoral anti. body consisted of both 2-ME resistant and sensitive antibodies already at 1 week. The cord sera contained only 2-ME resistant HI antibody which had a half life of 14 days in the unvaccinated newborn babies. In the vaccinated group of newborns there was an initial quicker elimination of IgG than in the unvaccinated babies. In addition, seroconversion was negligible in those babies whose cord sera had an initially very high HI antibody titre. Immunological implications of these findings have been discussed.
- Subjects
SMALLPOX vaccines; NEONATAL diseases; SKIN abnormalities; ALLERGIES; IMMUNIZATION; IMMUNOGLOBULINS; VIRUSES
- Publication
Scandinavian Journal of Immunology, 1973, Vol 2, Issue 3, p261
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1973.tb02036.x