We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Biology and therapeutic targeting of tumour-associated macrophages.
- Authors
Beltraminelli, Tim; De Palma, Michele
- Abstract
Macrophages sustain tumour progression by facilitating angiogenesis, promoting immunosuppression, and enhancing cancer cell invasion and metastasis. They also modulate tumour response to anti-cancer therapy in pre-clinical models. This knowledge has motivated the development of agents that target tumour-associated macrophages (TAMs), some of which have been investigated in early clinical trials. Here, we provide a comprehensive overview of the biology and therapeutic targeting of TAMs, highlighting opportunities, setbacks, and new challenges that have emerged after a decade of intense translational and clinical research into these multifaceted immune cells.
- Subjects
BIOLOGY; MACROPHAGES; ANIMAL models in research; TRANSLATIONAL research; CANCER cells
- Publication
Journal of Pathology, 2020, Vol 250, Issue 5, p573
- ISSN
0022-3417
- Publication type
Article
- DOI
10.1002/path.5403