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- Title
Expression of JL1 Is an Effective Adjunctive Marker of Leukemia Cutis.
- Authors
Young Soo Park; So Hyung Park; Seo-Jeong Park; Youngji Kim; Kee-Taek Jang; Young Hyeh Ko; Mi-Woo Lee; Joo Ryung Huh; Chan-Sik Park
- Abstract
Context.-Specific differentiation of leukemia cutis (LC) from nonleukemic dermatoses is crucial to ensure proper treatment for the disease. Because of the exceptionally variable histologic features of LC and the frequent nonleukemic dermatoses in leukemia patients, identification of leukemic cells that infiltrate skin lesions is important. Here, we introduce JL1, a novel leukemiaassociated surface antigen, which is not expressed in mature human tissue but in cortical thymocytes and small subpopulations of bone marrow hematopoietic precursors. Objectives.-To assess the expression pattern of JL1 in LC and compare it with other commonly used markers. Also, to evaluate the expression of JL1 in other cutaneous lesions that need differential diagnoses. Design.-Immunohistochemical staining with anti-JL1 and other commonly used markers for LC was performed on paraffin-embedded skin biopsies from 32 cases of LC with acute lymphoblastic leukemia/lymphoma and acute myelogenous leukemia. Immunohistochemical staining score was evaluated in each case according to the proportion of positive tumor cells found. JL1 staining was also done on 96 reactive or neoplastic cutaneous lesions. Results.-JL1 was detected in 7 of 11 acute lymphoblastic leukemia/lymphoma LC (63.6%) and 7 of 21 acute myelogenous leukemia LC (33.3%), with invariably highstaining scores. None of the other cutaneous lesions or normal tissues expressed JL1. The expression pattern of JL1 was not altered in 2 patients with follow-up biopsies. Conclusions.-Our finding that JL1 is expressed exclusively and stably by leukemic cells suggests that it can be used as a useful adjunctive marker for initial diagnosis and follow-up biopsy of LC, particularly in cases of scarce infiltrates.
- Subjects
SKIN diseases; LEUKEMIA; CELL surface antigens; HEMATOPOIETIC agents; BIOPSY
- Publication
Archives of Pathology & Laboratory Medicine, 2010, Vol 134, Issue 1, p95
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/2008-0699-oar.1