The article profiles biophysicist Daniel J. Muller. It is stated that Muller is a faculty member in biosystems science and engineering at ETH Zurich, Basel, and chair of biophysics and bionanotechnology. It is noted that he has cofounded a research center with 28 research groups for molecular systems engineering. It is noted that Muller also used a new theoretical approach to calculate a map of the ligand binding free-energy landscape.