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- Title
A primer to scaffolded DNA origami.
- Authors
Castro, Carlos Ernesto; Kilchherr, Fabian; Kim, Do-Nyun; Shiao, Enrique Lin; Wauer, Tobias; Wortmann, Philipp; Bathe, Mark; Dietz, Hendrik
- Abstract
Molecular self-assembly with scaffolded DNA origami enables building custom-shaped nanometer-scale objects with molecular weights in the megadalton regime. Here we provide a practical guide for design and assembly of scaffolded DNA origami objects. We also introduce a computational tool for predicting the structure of DNA origami objects and provide information on the conditions under which DNA origami objects can be expected to maintain their structure.
- Subjects
DNA; COMPUTER-aided design; GEL electrophoresis; TRANSMISSION electron microscopy; HELICES (Algebraic topology); NANOTECHNOLOGY
- Publication
Nature Methods, 2011, Vol 8, Issue 3, p221
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.1570