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- Title
Association of Fibroblast Growth Factor (Fgf-21) as a Screening Biomarker for Chronic Progressive External Ophthalmoplesia.
- Authors
Dehkordi, Farnaz Farzaneh; Houshmand, Massoud; Sadeghizadeh, Majid; Kashkouli, Mohsen Bahmani; Javadi, Gholamreza
- Abstract
Purpose: To investigate whether or not fibroblast growth factor (FGF-21) can be used as a screening biomarker in chronic progressive external ophthalmoplesia (CPEO) patients. Methods: FGF-21 concentration was measured in the serum of 24 patients with CEPO phenotype and 24 control samples by enzyme-linked immunosorbent assay (ELISA) and determined the deletion of mitochondrial genome by multiplex polymerase chain reaction (PCR). Results: FGF-21 concentration in 50 % of CPEO patients showed notable differences from that in control subjects. FGF-21 concentration ratio in patient group, 2 disorder control groups (mitochondrial and non-mitochondrial) and normal group, respectively, was 294.87 ± 42.10 (p < 0.0001), 761.78± 75.07 (p < 0.0001), 124.26 ± 12.27 (p = 0.1203), 69.27 ± 10.09 (p = 0.2195). A statistically significant inverse correlation between FGF-21 concentration and age onset was found, with a significant difference (p < 0.05) in the age group = 19 years (mean FGF-21 concentration, 460.36 pg/mL) and for the age group = 51years (mean concentration FGF-21, 57.87 pg/mL. Surprisingly, there was no significant difference between FGF-21 concentration and age in the mid-age group (20 - 50 years) . Conclusion: These findings indicate that FGF-21 concentration significantly increases in CPEO patients like in other mitochondrial disorders and this factor can be used as a biomarker in primary diagnosis of mitochondrial disorders. In this regard, FGF-21 assay is only valid in teenagers and the > 50 years age group who show acute symptoms.
- Subjects
FIBROBLAST growth factors; BIOMARKERS; CHRONIC progressive external opthalmoplegia; SERUM; ENZYME-linked immunosorbent assay; MITOCHONDRIA; POLYMERASE chain reaction
- Publication
Tropical Journal of Pharmaceutical Research, 2014, Vol 13, Issue 3, p377
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v13i3.10