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- Title
Effects of testosterone on rat placental development.
- Authors
Satoshi Furukawa; Naho Tsuji; Seigo Hayashi; Yusuke Kuroda; Masayuki Kimura; Chisato Hayakawa; Kazuya Takeuchi; Akihiko Sugiyama
- Abstract
We investigated the morphological effects of testosterone on placental development in a rat model of polycystic ovarian syndrome (PCOS). Testosterone propionate (TP), which was subcutaneously administered to pregnant rats with 5 mg/animal from gestation day (GD) 14 to GD 18, induced a maternal weight reduction without mortality or clinical signs from GD 19 onwards. A decrease in fetal and placental weight, an increase in intrauterine growth retardation (IUGR) rates, and histological changes in the placenta were observed on GD 21 but not on GD15 or 17. Histopathologically, on GD 21, the trophoblast septa thickened, and the maternal sinusoids were narrowed in the labyrinth zone, resulting in a small placenta. Additionally, the placental weight, thickness, and histological morphology in the labyrinth zone on GD 21 in the TP-treated group were nearly identical to those on GD 17 in the control and TP-treated groups. Therefore, it was assumed that the testosterone-induced small placenta was induced in association with the developmental inhibition of the fetal part of the placentas from GD 17 onwards.
- Subjects
PLACENTA; RATS; FETAL growth retardation; WEIGHT loss; TESTOSTERONE; PREGNANCY in animals
- Publication
Journal of Toxicologic Pathology, 2022, Vol 35, Issue 1, p37
- ISSN
0914-9198
- Publication type
Article
- DOI
10.1293/tox.2021-0035