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- Title
İzole Sıçan Sural Sinirlerinde 4-Aminopiridin Tetiklemeli Potansiyellere Okskarbazepin'in Etkisi.
- Authors
Güven, Mustafa; Kahraman, İbrahim; Koç, Filiz; Bozdemir, Hacer; Sarica, Yakup; Günay, İsmail
- Abstract
Objective: Oxcarbazepine is used for the treatment of neuropathic pain syndromes. In the present study, we have investigated the effect of oxcarbazepine on the amplitude of compound action potentials (CAP), and the depolarizing after-potentials induced by 4- aminopyridine in the rat sural nerves which plays an important role of the neuropathic pain. Material and Method: The experiments were conducted with sucrose-gap technique, which is an electrophysiological method on the isolated wistar rat sural nerves. Effects of oxcarbazepine at 0.1- 0.8 mM on the nerve conduction and 4-aminopyridine (4-ap) induced depolarizing after potentials were investigated. Results: All concentrations of oxcarbazepine exerted a significant concentration- and frequency dependent reduction in the amplitude of CAP, and prolonged the rising and the ½ falling phase of the CAP (P<0.01). The tonic blocks were measured as 0.1 mM; 14.7 ± 1.7%, 0.8 mM; 73.3±3.0%, and the phasic blocks (100Hz) were 0.1 mM; 15.9 ± 1.4%, 0,8 mM; 96.6±3.3% (n=6). 2 mM 4-ap prolonged the falling phase of CAP and produced a depolarizing after-potential. Oxcarbazepine reduced the amplitude of the depolarizing afterpotential, which was more pronounced than that of the amplitude of the CAP in the presence of 4-aminopyridine. Conclusions: The findings showed that oxcarbazepine may reduce the amplitude of depolarizing afterpotentials in the rat sural nerves which contributes to sensory signaling and may play a role in neuropathic pain. We concluded that the results may be relevant to our understanding of effect of oxcarbazepine on sensory nerves and its therapeutic role on neuropathic pain.
- Subjects
ION channels; ANTICONVULSANTS; AMINOPYRIDINES; SENSORY neurons; PAIN management
- Publication
Journal of Neurological Sciences, 2010, Vol 27, Issue 2, p139
- ISSN
1300-1817
- Publication type
Article