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- Title
Symptoms of depression impact the course of lung function in adolescents and adults with cystic fibrosis.
- Authors
Fidika, Astrid; Herle, Marion; Goldbeck, Lutz
- Abstract
Background Epidemiological studies report high rates of depression among patients with cystic fibrosis (CF). Assuming a causal relationship between depression and the progression of CF, our hypothesis is that elevated symptoms of depression would be a predictor of worse lung function after two years. Methods In the context of the TIDES study, 473 German patients with CF (age 12-53 years, FEV1% predicted M = 66.2, range 13-137) completed the Hospital Anxiety and Depression Scale (HADS). Lung function (FEV1% predicted) was assessed at baseline and followed up two years later. Repeated measures analysis was performed involving the level of FEV1% and the level of depressive symptoms at baseline as independent factors and FEV1% at the 2-year follow-up as the dependent variable. Results Interaction between lung function and depression at baseline significantly affected the change in lung function at the 2-years observation interval. The largest decline in FEV1% occurred in depressed patients with good lung function at baseline. In contrast, patients without any clinically relevant depressive symptoms and with poor lung function at baseline showed a slight increase two years later. Conclusion The findings emphasise the need to screen patients with CF for symptoms of depression and to treat co-morbid depression.
- Subjects
SYMPTOMS; MENTAL depression; CYSTIC fibrosis; LUNG physiology; DISEASES in teenagers; DISEASES in adults; PATIENTS
- Publication
BMC Pulmonary Medicine, 2014, Vol 14, Issue 1, p231
- ISSN
1471-2466
- Publication type
Article
- DOI
10.1186/1471-2466-14-205