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- Title
Effect of Topical Honey Application Along with Intralesional Injection of Glucantime on Cutaneus Leishmaniasis Treatment.
- Authors
Zadeh, Mohammad Ali Nilforosh; Moradi, Shahram; Derakhshan, Roya; Haftbaradaran, Elaheh
- Abstract
INTRODUCTION Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey on the chronic ulcers and its reported efficacy on the cutaneous leishmaniasis, we performed a study to evaluate better the antiinflammatory effect of honey in cutaneous leishmaniasis and its final Scar. METHOD In a clinical trial study 100 patients were selected randomely in 2 groups, among referred patients to Skin Disease and Leishmaniasis Research Center. One group was treated with intralesional glucantime for one week and the other group was treated with intralesional glucantime and also topical application of honey twice a day for a week. The patients were visited twice at each week and at the end of second, third and fourth month at the end of treatment. They were followed up and the results were evaluated clinically. RESULT In this study 45 patients that had cutaneous leishmaniasis were treated with intra lesional glucantime and 45 patients were treated with honey and glucantime and 10 patients were excluded from study. In the group that was treated with glucantime at the end of treatment 32 patients(71.1%) had improved and in the group that treated honey along with glucantime 23 people (51.1%) had improved, which showed a significant difference in two groups (p=0.04). CONCLUSION It appears that drug interaction and prevention of intra lesional glucantime bioavailability due to use of topical honey have resulted in a significant decrease in improvement of cutaneous leishmaniasis lesions.
- Subjects
IRAN; THERAPEUTIC use of honey; CUTANEOUS leishmaniasis; ANTI-inflammatory agents; DRUG interactions
- Publication
Malaysian Journal of Medical Sciences, 2007, Vol 14, Issue 1, p111
- ISSN
1394-195X
- Publication type
Article