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- Title
Crystal structure of the vitamin B<sub>3</sub> transporter PnuC, a full-length SWEET homolog.
- Authors
Jaehme, Michael; Guskov, Albert; Slotboom, Dirk Jan
- Abstract
PnuC transporters catalyze cellular uptake of the NAD+ precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3 + 1 + 3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.
- Subjects
MEMBRANE topology (Biology); CHROMOSOMAL translocation; NICOTINAMIDE; RIBOSIDES; CRYSTAL structure research
- Publication
Nature Structural & Molecular Biology, 2014, Vol 21, Issue 11, p1013
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2909