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- Title
Functional implications of genome topology.
- Authors
Cavalli, Giacomo; Misteli, Tom
- Abstract
Although genomes are defined by their sequence, the linear arrangement of nucleotides is only their most basic feature. A fundamental property of genomes is their topological organization in three-dimensional space in the intact cell nucleus. The application of imaging methods and genome-wide biochemical approaches, combined with functional data, is revealing the precise nature of genome topology and its regulatory functions in gene expression and genome maintenance. The emerging picture is one of extensive self-enforcing feedback between activity and spatial organization of the genome, suggestive of a self-organizing and self-perpetuating system that uses epigenetic dynamics to regulate genome function in response to regulatory cues and to propagate cell-fate memory.
- Subjects
GENOMES; NUCLEIC acids spectra; NUCLEOTIDES; CELL nuclei; GENOMICS; GENE expression; GENETIC regulation
- Publication
Nature Structural & Molecular Biology, 2013, Vol 20, Issue 3, p290
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2474