We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Santral Adenozinerjik Sistem ve Klinik Önemi.
- Authors
Kayir, Hakan; Uzbay, Tayfun
- Abstract
Adenosine is a neuromodulator widely distributed throughout the body. Since it is continuously synthesized, it can be concluded that there is a basal adenosinergic tonus, which has inhibitory effects in general. All of the three adenosine receptors are G-protein coupled. While A1 and A3 receptor subtypes inhibit adenylate cyclase, A2 subtypes activates it. A1 and A2A receptor subtypes, which bind adenosine with high affinity, are responsible for the basal adenosinergic tonus in physiological conditions. The most widely distributed subtype, A1, is concentrated particularly in cerebral cortex, cerebellum and hippocampus. Adenosine has intense interactions with other receptor systems. There are antagonistic interactions between A1 dopamine D1 and between A2 and D2 receptors. Adenosine is implicated in physiological processes such as initiation and maintenance of sleep, modulation of arousal, and control of cerebral blood flow in response to energy demand of the brain. Adenosine is also implicated in cell-protection in pathological conditions like hypoxia and ischemia. Adenosine might be important in the pathophysiology of anxiety, epilepsy, depression, schizophrenia, Parkinson's disease, and addiction. The current literature about the central adenosinergic system is reviewed.
- Subjects
ADENOSINES; ADENINE; PROTEINS; BIOMOLECULES; ORGANIC compounds; DEVELOPMENTAL disabilities
- Publication
Klinik Psikofarmakoloji Bulteni, 2004, Vol 14, Issue 3, p159
- ISSN
1017-7833
- Publication type
Article