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- Title
High prevalence of vitamin B-12 insufficiency in patients with Crohn's disease.
- Authors
Misora Ao; Hidemi Tsuji; Kenichiro Shide; Yuki Kosaka; Akari Noda; Nobuya Inagaki; Hiroshi Nakase; Kiyoshi Tanaka; Ao, Misora; Tsuji, Hidemi; Shide, Kenichiro; Kosaka, Yuki; Noda, Akari; Inagaki, Nobuya; Nakase, Hiroshi; Tanaka, Kiyoshi
- Abstract
<bold>Background and Objectives: </bold>In Crohn's disease (CD), belonging to inflammatory bowel disease, the small intestine is involved in most cases. Most frequently affected is the distal ileum, where vitamin B-12 is specifically absorbed. Therefore, malabsorption of vitamin B-12 is quite likely to occur in patients with CD. In this study, we have studied the vitamin B-12 status in CD patients.<bold>Methods and Study Design: </bold>Forty eight patients with CD were evaluated for their food intake, and circulating concentrations of vitamin B-12, folic acid, and homocysteine (Hcy) as a sensitive marker for the insufficiency of these vitamins and a risk factor of atherosclerosis.<bold>Results: </bold>Plasma Hcy concentration was significantly correlated with serum vitamin B-12 concentration alone, and 60.4 % of the subjects had hyperhomocysteinemia. Receiver Operating Characteristics (ROC) analysis showed that serum concentration of vitamin B-12, but not folic acid, predicted hyperhomocysteinemia. Their intake of vitamin B-12 was much higher than the Japanese RDA, but not correlated with blood concentrations of vitamin B-12 or Hcy, probably due to malabsorption.<bold>Conclusions: </bold>Vitamin B-12 insufficiency and hyperhomocysteinemia were highly prevalent in CD patients. Recently, the significance of extra-intestinal complications of CD has been increasingly recognized, and our finding is likely to be of clinical importance.
- Subjects
CROHN'S disease; VITAMIN B12 deficiency; INFLAMMATORY bowel diseases; MALABSORPTION syndromes; INGESTION; FOLIC acid; HYPERHOMOCYSTEINEMIA; BIOMARKERS; VITAMIN D; HOMOCYSTEINE; DISEASE prevalence; RECEIVER operating characteristic curves; DISEASE complications; VITAMIN deficiency; DISEASE risk factors
- Publication
Asia Pacific Journal of Clinical Nutrition, 2017, Vol 26, Issue 6, p1076
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.022017.13