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- Title
Fish, long chain omega-3 polyunsaturated fatty acids consumption, and risk of all-cause mortality: a systematic review and dose-response meta-analysis from 23 independent prospective cohort studies.
- Authors
Yi Wan; Jusheng Zheng; Fenglei Wang; Duo Li; Wan, Yi; Zheng, Jusheng; Wang, Fenglei; Li, Duo
- Abstract
<bold>Background and Objectives: </bold>The consumption of fish and long chain omega-3 polyunsaturated fatty acids (n-3 PUFA) may influence the risk of all-cause mortality, but the findings have been inconsistent. The current systematic review and meta-analysis is to clarify the association between fish and long chain n-3 PUFA consumption with risk of all-cause mortality.<bold>Methods and Study Design: </bold>Studies published before March 2017 were identified through electronic searches using PubMed, Scopus and Web of Science database. We included prospective cohort studies that reported relative risks with 95% CI of all-cause mortality for fish and long chain n-3 PUFA consumption. Results were combined using a random effects model.<bold>Results: </bold>Twenty-three prospective cohorts with a total of 1,035,416 participants were included. Twenty-two pooled studies involving 985,126 participants indicated that fish intake was associated with 6% (RR: 0.94; 95% CI: 0.90, 0.98) reduction in risk of all-cause mortality. Six studies with 430,579 participants investigated the association between long chain n-3 PUFA and all-cause mortality risk, the relative risk for highest versus lowest category was 0.86 (95% CI: 0.80, 0.93). Doseresponse analysis suggested that the risk of all-cause mortality was reduced by 7% (RR: 0.93; 95% CI: 0.88, 0.99) for every 0.2 g per day increment in long chain n-3 PUFA consumption.<bold>Conclusions: </bold>Current meta-analysis indicates that both fish and long chain n-3 PUFA consumption are inversely associated with risk of all-cause mortality. These findings could have public health implications with regard to lowering risk of all-cause mortality through dietary interventions.
- Subjects
UNSATURATED fatty acids; ACIDOLYSIS; MORTALITY; FATTY acids; ALKENES; CONFIDENCE intervals; DOSE-response relationship in biochemistry; FISHES; INGESTION; LONGITUDINAL method; MEDLINE; META-analysis; OMEGA-3 fatty acids; ONLINE information services; SYSTEMATIC reviews
- Publication
Asia Pacific Journal of Clinical Nutrition, 2017, Vol 26, Issue 5, p939
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.072017.01