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- Title
Does moderate red wine consumption protect DNA and lipid systems from oxidative damage: in vivo measurements in young and old humans?
- Authors
Micallef, M. A.; Lewandowski, P.
- Abstract
Background -- Red wine is a rich source of antioxidants, which may protect the body from oxidative stress. Oxidative stress has been shown to increase with age and is a major determinant of age-related disease. To date little is known about the potential of red wine to reduce the degree of oxidative stress in humans. Objective -- To determine the in vivo effects of moderate red wine consumption on DNA, lipid peroxidation, blood lipid, glucose profiles and whether these effects are dependent on age. Design -- Twenty young (18-30yrs) and 20 older (≥50yrs) volunteers were recruited. Each of the groups comprised of 10 treatment and 10 control subjects. Treatment subjects consumed 400 mL of red wine each day for two weeks and control subjects abstained from alcohol for two weeks. Blood samples were collected before and after the study periods and were used for analysis of glutathione (GSH) a marker of DNA damage and malondialdehyde (MDA) a marker of lipid peroxidation. Blood glucose and lipid profiles were also analysed. Outcomes -- Results from this study show no significant changes in serum glucose, plasma cholesterol, triglycerides, HDL and LDL concentrations in all control and treatment groups. However, significant reductions in MDA were found for both young (pre 5.5µM, post 3.1µM, P =0.007) and old (pre 3.4 µM, post 1.1 µM, P <0.001) treatment groups, as well as significant reductions in GSH in young (pre 0.7µM, post 0.2µM, P = 0.026) and old (pre 2.4µM, post 1.0µM, P <0.001) treatment groups. Conclusions -- This study suggests that moderate consumption of red wine induces a significant decrease in lipid and DNA oxidation, but has no affect on blood glucose and lipid profiles in young and old individuals. It may be implied from this data that red wine provides oxidative protection of lipid systems and DNA in circulation.
- Subjects
WINES; DNA; LIPIDS; OXIDATION; ALCOHOLIC beverages
- Publication
Asia Pacific Journal of Clinical Nutrition, 2005, Vol 14, pS65
- ISSN
0964-7058
- Publication type
Article