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- Title
Synthesis and Antimicrobial Activity of 3-[(4-Substituted) (2-oxo-1,3-oxazolidin-3-yl) phosphoryl]- 1,3-oxazolidin-2-ones.
- Authors
Reddy, Mudumala V. N.; Sankar, A. U. Ravi; Kumar, B. Siva; Reddy, C. Suresh; Raju, C. Naga
- Abstract
3-[(4-Substituted) (2-oxo-1,3-oxazolidin-3-yl)-phosphoryl]-1,3-oxazolidin-2-ones (4a--j) were synthesized through a two-step process. Bis-(2-oxo-1,3-oxazolidin-3-yl)-phosphonic chloride (2) prepared by the reaction of two moles of oxazolidin-2-one (1) with phosphorus oxychloride in dry tetrahydrofuran in the presence of triethylamine and treatment with various heterocyclic aromatic and aliphatic amines under the same experimental conditions afforded the title compounds (4a--j). They were characterized by elemental analysis, IR, NMR(¹H, 13C and 31P) and mass spectroscopy. Their antimicrobial activities were also evaluated.
- Subjects
OXYCHLORIDES; TETRAHYDROFURAN; ALIPHATIC compounds; AMINES; MASS spectrometry
- Publication
South African Journal of Chemistry, 2008, Vol 61, p43
- ISSN
0379-4350
- Publication type
Article