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- Title
On contrast mechanisms in p-space imaging.
- Authors
Straub, Sina; Ladd, Mark E.; Wetscherek, Andreas; Laun, Frederik B.
- Abstract
Purpose The effects of microstructure on susceptibility mapping have recently received increasing attention. In this work, the capability of p-space imaging to resolve subvoxel structure and susceptibility is assessed. Methods In a simulation study, the p-space contrast of axon bundles comprised of hollow cylinders is investigated. Various axon and susceptibility distributions are considered and compared with the corresponding case of a voxel with homogeneous substructure of the order of the voxel size. Results MR signal behavior for p-space imaging of a voxel containing axon bundles and a voxel containing homogeneous substructure are nearly identical. Conclusion p-Space imaging resolves subvoxel structure of the order of the voxel size. Due to dephasing effects, strong susceptibility variations alter p-space contrast. However, p-space contrast is not directly linked to the susceptibility of the axon compartment. Magn Reson Med 75:2526-2533, 2016. © 2015 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2016, Vol 75, Issue 6, p2526
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.25812