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- Title
Efficient Palladium-Catalyzed Synthesis of 2-Aryl Propionic Acids.
- Authors
Neumann, Helfried; Sergeev, Alexey G.; Spannenberg, Anke; Beller, Matthias; Pérez Sestelo, José
- Abstract
A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps.
- Subjects
PROPIONIC acid; ETHYLENE dibromide; ARYL iodides; ARYL bromides; ANTI-inflammatory agents; STYRENE
- Publication
Molecules, 2020, Vol 25, Issue 15, p3421
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25153421