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- Title
Targeting the Epidermal Growth Factor Receptor in Colorectal Cancer: Advances and Controversies.
- Authors
Italiano, Antoine
- Abstract
Colorectal cancer (CRC) is the second leading cause of cancer death in the western world. Even with the significant improvement in traditional chemotherapy, there remain limitations with this treatment. One of the most promising new targets in the treatment of CRC is the epithelial growth factor receptor (EGFR). Agents that inhibit the EGFR have demonstrated clinical activity as single agents and in combination with chemotherapy and the most promising of these agents is cetuximab, which blocks the binding of EGF and transforming growth factor-α (TGF-α) to EGFR. Thus, the finding that monoclonal antibodies against EGFR caused a response in patients, and reversed resistance to chemotherapy, was exciting news. However, expression of EGFR did not correlate with clinical benefit. Clearly, the search for markers of response to treatment against EGFR must go on. Copyright © 2006 S. Karger AG, Basel
- Subjects
EPIDERMAL growth factor; CANCER patients; PHARMACOLOGY; THERAPEUTICS; DRUG therapy; GROWTH factors; IMMUNOGLOBULINS; COLON cancer
- Publication
Oncology, 2006, Vol 70, Issue 3, p161
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000093092