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- Title
Effect of the GABAergic System on Memory Formation and State-Dependent Learning Induced by Morphine in Rats.
- Authors
Zarrindast, Mohammad-Reza; Noorbakhshnia, Maryam; Motamedi, Freshteh; Haeri-Rohani, Ali; Rezayof, Ameneh
- Abstract
In the present study, the effects of intraperitoneal injections of GABAA receptor agonist and antagonist on memory formation and morphine state-dependent learning were investigated in rats. Pre-training administration of morphine (1-15 mg/kg) in a step-down passive avoidance task induced state-dependent learning with impaired memory retrieval on the test day. The impairment of memory was restored after the pre-test administration of the same dose of morphine. The pre-test administration of the GABAA receptor agonist, muscimol (0.01, 0.05 and 0.1 mg/kg), significantly decreased state-dependent retrieval induced by pre-test morphine (5 mg/kg). The state-dependency effect of morphine (1 mg/kg) was significantly potentiated by the pre-test administration of the GABAA receptor antagonist, bicuculline (0.125, 0.25 and 0.5 mg/kg). Furthermore, the pre-training injection of muscimol (0.01 mg/kg) impaired memory retrieval which was restored by pre-test morphine (1, 3 and 5 mg/ kg) administration. However, the pre-training administration of bicuculline did not affect retention by itself. In addition, amnesia induced by pre-training morphine (5 mg/kg) was significantly reversed in rats which had received pre-test injections of muscimol (0.01, 0.05 and 0.1 mg/kg). Pre-test injections of bicuculline (0.125, 0.25 and 0.5 mg/kg) significantly decreased morphine-induced amnesia. It is concluded that the GABAA receptor mechanisms may be involved in the memory formation and it is postulated that these receptors may play an important role in morphine state-dependent learning.
- Subjects
INTRAPERITONEAL injections; GABA; AMINO acid neurotransmitters; DRUG administration; AMINOBUTYRIC acid; LABORATORY rats
- Publication
Pharmacology, 2006, Vol 76, Issue 2, p93
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000089934