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- Title
Chemical structure and biological activity of steroidal saponins from Furcraea gigantea.
- Authors
da Silva, Bernadete Pereira; Campos, Patricia Oliveira; Parente, Jose Paz
- Abstract
A new bisdesmosidic furostanol saponin, along with a known spirostanol saponin, furcreastatin, were isolated from Furcraea gigantea Vent. (Agavaceae). The structure of the new saponin was elucidated as 3-[( O-6-deoxy- α-L-mannopyranosyl-(1→4)- O-β-D-glucopyranosyl-(1å 3)- O-[ O-β-D-glucopyranosyl-(1→3)- β-D-glucopyranosyl-(1→2)- O-β-D-glucopyranosyl-(1→4)- β-D-galactopyranosyl)oxy]-(3 β, 5 α, 25 R)-26-( β-D-glucopyranosyloxy)-22-hydroxyfurost-12-one. The structural identification was performed using a combination of spectroscopic techniques and chemical conversions. Furcreastatin showed a powerful haemolytic effect in the in vitro assay, but the new bisdesmosidic furostanol saponin demonstrated only a significant inhibition of the capillary permeability activity.
- Subjects
SAPONINS; GLUCOSIDES; FURCRAEA; ASPARAGACEAE; FIBER plants; CHEMICAL structure; CONSTITUTION of matter
- Publication
Chemistry of Natural Compounds, 2006, Vol 42, Issue 3, p316
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-006-0109-3