We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Defective endovascular trophoblast invasion in the first trimester is associated with increased maternal serum ischemia-modified albumin.
- Authors
Aris T. Papageorghiou; Federico Prefumo; Karin Leslie; David C. Gaze; Paul O. Collinson; Baskaran Thilaganathan
- Abstract
BACKGROUND Ischemia-modified albumin (IMA), a protein elevated in cardiac ischemia, is also increased to supra-physiological levels in early normal pregnancy. This finding supports the hypothesis that normal trophoblast development is stimulated by a hypoxic intrauterine environment. The aim of this study was to examine whether first trimester IMA levels are further elevated with defective trophoblast development. METHODS Prospective study of healthy women with singleton pregnancies undergoing nuchal translucency assessment at 11–14 weeks. First trimester maternal serum IMA concentrations in those subsequently developing pre-term pre-eclampsia (n = 19) were compared to randomly chosen controls with normal pregnancy outcome (n = 69). RESULTS Median first trimester serum IMA concentrations were significantly higher in women who subsequently developed pre-eclampsia (median 126.5 kU/L, interquartile range (IQR) 114.33–134.36 kU/L) when compared to those with normal pregnancy outcome (median 115.01 kU/L, IQR 102.29–124.81 kU/L, P = 0.02). CONCLUSIONS Maternal serum IMA levels are elevated in the first trimester in women with pre-eclampsia, a clinical manifestation of defective endovascular trophoblast development. This suggests that abnormally high intrauterine hypoxia and subsequent reperfusion oxidative damage may be associated with defective trophoblast development. First trimester serum IMA may be a potential biomarker for abnormal placental development.
- Subjects
TROPHOBLASTIC tumors; ALBUMINS; ISCHEMIA; BLOOD circulation disorders
- Publication
Human Reproduction, 2008, Vol 23, Issue 4, p803
- ISSN
0268-1161
- Publication type
Article