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- Title
Conservative treatment in epithelial ovarian cancer: results of a multicentre study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Socit Franaise d'Oncologie Gyncologique).
- Authors
Philippe Morice; Eric Leblanc; Annie Rey; Marc Baron; Denis Querleu; Pierre Duvillard; Catherine Lhomm; Damienne Castaigne; Jean Marc Classe; Pascal Bonnier
- Abstract
BACKGROUND: Results of conservative management of epithelial ovarian cancer (EOC) remain controversial in the literature. The aim of this study was to assess the clinical outcomes and fertility following fertility-sparing surgical management of EOC in a retrospective multicentre study. METHODS: A multicentre retrospective study was performed by members of two French groups. Six inclusion criteria were defined: (i) Histological review by the same pathologist; (ii) age =40 years; (iii) conservative management; (iv) complete peritoneal staging; (v) delivery of a platinum-based chemotherapy in stage =IC; and (vi) follow-up >1 year. RESULTS: Thirty-four patients fulfilled the inclusion criteria: 30 had stage IA disease; three had stage IC and one had stage IIA. Eleven patients had recurrence: 10 patients had invasive disease and one had borderline recurrence. Among 10 patients with invasive recurrence, initial stage and grade were: stage IA G1, n=1; stage IA G2, n=4; stage IA G3, n=1; and stage=IC, n=4. All patients with stage >?IA had recurrence. Ten pregnancies were observed in nine patients. CONCLUSION: Conservative surgery for patients with EOC could be considered in young patients with stage IA G1 disease. This procedure should not be performed in patients with FIGO stage >?IA.
- Subjects
CANCER treatment; OVARIES; ONCOLOGY; FERTILITY
- Publication
Human Reproduction, 2005, Vol 20, Issue 5, p1379
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/deh777