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- Title
The accuracy of serum interleukin-6 and tumour necrosis factor as markers for ovarian torsion.
- Authors
Cohen, Shlomo B.; Wattiez, Arnaud; Stockheim, David; Seidman, Daniel S.; Lidor, Arie L.; Mashiach, Shlomo; Goldenberg, Mordechai; Cohen, S B; Wattiez, A; Stockheim, D; Seidman, D S; Lidor, A L; Mashiach, S; Goldenberg, M
- Abstract
<bold>Background: </bold>The aim of this study was to investigate a possible role for interleukin-6 (IL-6) and tumour necrosis factor (TNF-alpha) as pre-operative markers for the diagnosis of ovarian torsion.<bold>Methods: </bold>Twenty consecutive patients admitted to the gynaecological emergency room with suspected clinical diagnosis of ovarian torsion were prospectively assigned to the study. Blood samples were drawn pre-operatively and examined for serum concentrations of IL-6 and TNF-alpha. Surgeons were blinded to laboratory results prior to laparoscopy.<bold>Results: </bold>The pre-operative diagnosis of ovarian torsion was confirmed during an urgent diagnostic laparoscopy in 8 (40%) patients. The surgical diagnosis among the remaining 12 patients was a large ovarian cyst not in torsion. In six out of eight (75.0%) patients with ovarian torsion serum IL-6 concentrations were elevated. None of the 12 patients without torsion had elevated serum IL-6 concentrations. This difference was statistically significant (P < 0.001). There was no significant difference in the proportion of women with elevated serum TNF-alpha concentrations, two of eight (25.0%) patients with torsion and four of 12 (33.3%) control cases.<bold>Conclusions: </bold>Elevated serum IL-6 concentrations, but not serum TNF-alpha concentrations, were significantly associated with the occurrence of ovarian torsion. In patients with vague clinical signs of ovarian torsion, serum IL-6 might help to distinguish which patients should undergo diagnostic laparoscopy.
- Subjects
INTERLEUKINS; LONGITUDINAL method; OVARIAN diseases; TUMOR necrosis factors; OVARIAN cysts; BLIND experiment; OSMOLAR concentration; TORSION abnormality (Anatomy)
- Publication
Human Reproduction, 2001, Vol 16, Issue 10, p2195
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/16.10.2195