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- Title
Design of task-specific ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate for multicomponent synthesis of 3,3′-disubstituted oxindoles.
- Authors
Dige, Nilam; Korade, Suyog; Pore, Dattaprasad
- Abstract
We have designed and synthesized an efficient novel task-specific ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate [EAHEPiPY] [AlCl]. Its catalytic efficiency was explored for multicomponent reaction of isatin(s), malononitrile, and indole(s) furnished corresponding 3,3′-disubstituted oxindoles via tandem Knoevenagel/Michael addition reaction in excellent yield at 80 °C in mixed solvent system, water: ethanol (80:20%). Graphical Abstract:
- Subjects
IONIC liquids; OXINDOLES; ISATIN; MALONONITRILE; MICHAEL reaction
- Publication
Research on Chemical Intermediates, 2017, Vol 43, Issue 12, p7029
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-017-3034-0