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- Title
The effect of neurodegenerative diseases on the subventricular zone.
- Authors
Curtis, Maurice A.; Faull, Richard L. M.; Eriksson, Peter S.
- Abstract
During brain development, one of the most important structures is the subventricular zone (SVZ), from which most neurons are generated. In adulthood the SVZ maintains a pool of progenitor cells that continuously replace neurons in the olfactory bulb. Neurodegenerative diseases induce a substantial upregulation or downregulation of SVZ progenitor cell proliferation, depending on the type of disorder. Far from being a dormant layer, the SVZ responds to neurodegenerative disease in a way that makes it a potential target for therapeutic intervention.
- Subjects
NEURODEGENERATION; CELL proliferation; NEURONS; DEGENERATION (Pathology); NERVOUS system; NEUROSCIENCES
- Publication
Nature Reviews Neuroscience, 2007, Vol 8, Issue 9, p712
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn2216