We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reversible posterior leukoencephalopathy syndrome following carboplatin and paclitaxel in cervical cancer: Case report.
- Authors
Ouchane, Karima; Bellefkih, Fatima Zahra; Benchakroun, Nadia; Bourhafour, Mouna; Chekrine, Tarik; Bouchbika, Zineb; Jouhadi, Hassan; Tawfiq, Nezha; Sahraoui, Souha
- Abstract
Posterior reversible leukoencephalopathy is a rare radio-clinical entity that has gained increasing recognition over the last two decades. It is associated with various etiologies: arterial hypertension, autoimmune diseases, chemotherapy, and immunosuppressive drugs. Several cases have already been reported following cancer therapy. Posterior reversible leukoencephalopathy is characterized by capital clinical signs (headache, seizures, confusional syndrome, and visual disorders) and radiological abnormalities (cerebral edema predominantly in the posterior regions). We report the case of a 38-year-old female patient diagnosed with posterior reversible leukoencephalopathy after receiving Carboplatin and Paclitaxel chemotherapy for recurrent cervical cancer, which was revealed by a generalized seizure. Brain magnetic resonance imaging showed T2 Flair hyper signals in the parieto-occipital regions. This complication is rare but is probably underdiagnosed due to a lack of awareness and limited hindsight. Rapid diagnosis is essential to prevent acute neurological complications, which can be life-threatening or functionally crippling regardless of neoplasia.
- Subjects
POSTERIOR leukoencephalopathy syndrome; LEUKOENCEPHALOPATHIES; CERVICAL cancer; CARBOPLATIN; SYMPTOMS; PACLITAXEL
- Publication
SAGE Open Medical Case Reports, 2024, p1
- ISSN
2050-313X
- Publication type
Case Study
- DOI
10.1177/2050313X241257444