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- Title
Effectiveness of Triple Drug Fixed Dose Combination Inhaled Therapy in Severe COPD Patients.
- Authors
Patel, Vrunda B.; Bhatt, Palak H.; Rajguru, Nikita V.; Jindal, Savita; Tripathi, Sanjay; Kapadia, Vishakha K.
- Abstract
Rationale: According to GOLD 2018 guidelines, inhaled corticosteroids are recommended along with long acting muscarinic antagonist (LAMA) and long acting beta-2 agonist (LABA) inhaler medications in Group D COPD patients who show frequent exacerbations and symptom severity. Therefore, the use of triple drug inhaled medication in such severe COPD patients become necessary. Objectives: To know the effectiveness of inhaled triple drug medication in relation to spirometry, exercise tolerance, symptom control and prevention of exacerbations in severe COPD patients. Method: 25 severe COPD patients were included in this hospital based study. Before initiating the triple drug inhaled medication the baseline parameters such as spirometry ( FEV1), exercise tolerance (6 minute walking distance) and symptom control(CAT score, MMRC dyspnoea grading) are measured. 2 monthly follow-up till 6months of the study period is done. At each visit all the baseline parameters are reassessed. Result: There is statistically significant (p=<0.01) improvement in the FEV1, CAT scoring, MMRC grading, 6 Minute Walking Distance in the 25 subjects following initiation of treatment with the triple drug inhaler medication over 6months observation period. Conclusion: Triple drug inhaler medication in severe COPD patients is effective in improving airflow obstruction, symptom control, exercise tolerance and prevention of exacerbations.
- Subjects
EXERCISE tolerance; MUSCARINIC antagonists; DRUG abuse; ADRENOCORTICAL hormones
- Publication
National Journal of Medical Research, 2018, Vol 8, Issue 1, p21
- ISSN
2249-4995
- Publication type
Article