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- Title
Genistein suppresses the inflammation and GSK-3 pathway in an animal model of spontaneous ovarian cancer.
- Authors
ERTEN, Füsun; YENİCE, Engin; ORHAN, Cemal; E. R., Beşir; DEMİREL ÖNER, Pınar; DEFO DEEH, Patrick Brice; ŞAHİN, Kazım
- Abstract
Background/aim: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer. Materials and methods: A total of 300 laying hens were distributed into three groups as follows: group 1, animals fed a standard diet (comprising 22.39 mg of genistein/kg of diet); groups 2 and 3, animals fed a standard diet reconstituted with supplementation of 400 mg or 800 mg of genistein/kg of diet, respectively. Results: Genistein modulated the inflammatory biomarkers by decreasing serum tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF) compared with control (p < 0.001). Moreover, it upregulated insulin receptor substrate-1 (p-IRS-1) and protein kinase B (p-AKT), but downregulated GSK-3a and ß after treatment. It acts in a dose-dependent manner. Conclusion: Genistein exhibited an anticancer effect by reducing proinflammatory biomarkers levels and inhibiting GSK-3 expression in the ovaries of old laying hens. It is a potential candidate in the chemoprevention and/or treatment of ovarian cancer.
- Subjects
SOY proteins; OVARIAN cancer; VASCULAR endothelial growth factors; GENISTEIN; PROTEIN kinase B; DISEASE risk factors; GLYCOGEN synthase kinase-3
- Publication
Turkish Journal of Medical Sciences, 2021, Vol 51, Issue 3, p1465
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-2007-254