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- Title
Some statistical memes which sound correct but aren't quite: Application to the analysis of observational databases used in learning health systems.
- Authors
Samsa, Gregory P.
- Abstract
We consider four memes, correct within the context of randomized trials but requiring modification for the analysis of the observational databases typically associated with learning health systems: (a) the right answer always requires randomization; (b) a bigger database is always a better database; (c) statistical adjustment always works if based on a large enough database; and (d) always make a formal adjustment when testing multiple hypotheses. The rationale for these memes within the context of randomized trials is discussed, and the memes are restated in a fashion that is consistent with learning health systems.
- Subjects
MEMES; INSTRUCTIONAL systems; DATABASES; SOUND
- Publication
Learning Health Systems, 2020, Vol 4, Issue 3, p1
- ISSN
2379-6146
- Publication type
Article
- DOI
10.1002/lrh2.10219