We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tumoral Expression of CD44 and HIF1α Predict Stage I Oral Cavity Squamous Cell Carcinoma Outcome.
- Authors
Dunkel, Johannes; Vaittinen, Samuli; Koivunen, Petri; Laranne, Jussi; Mäkinen, Markus J.; Tommola, Satu; Irjala, Heikki
- Abstract
Objectives/Hypothesis No biomarkers are used to estimate the prognosis in oral cavity squamous cell carcinoma (OSCC). In our previously published work, we have reported the prognostic value of CD44 and hypoxia inducible factor (HIF)−1α in patients with stage I disease. Study Design In this study, we tested our previous observations in a larger cohort. We also studied the predictive value of common lymphatic endothelial and vascular endothelial receptor (CLEVER)−1 in this material. Methods CD44, HIF1α, and CLEVER-1 were immunohistochemically analyzed in paraffin-embedded tissue material of stage I OSCC patients treated at three Finnish university hospitals. Microscopy results were correlated with OSCC outcome. Results As in our pilot study, the CD44lowHIF1αhigh signature was associated with poorer disease-free survival. Clear correlations between CLEVER-1 expression and clinical outcome were not evident. Conclusion Our results suggest that immunohistochemistry of CD44 and HIF1α may be useful in identification of patients with poor prognoses. These parameters could be used to select the optimal treatment modalities for stage I OSCC patients. Level of Evidence 2b.
- Subjects
SQUAMOUS cell carcinoma; DENTAL pulp cavities; VASCULAR endothelial cells; HYPOXIA-inducible factor 1; MICROSCOPY; PROGNOSIS
- Publication
Laryngoscope Investigative Otolaryngology, 2016, Vol 1, Issue 1, p6
- ISSN
2378-8038
- Publication type
Article
- DOI
10.1002/lio2.3